(New York Knicks @ Brooklyn Nets - 7:30 p.m.)
What to watch: Brooklyn's rotation/ Kevin Knox's second game
The Nets have eight new faces for coach Kenny Atkins to incorporate on a nightly basis, he'll get his first chance to see some new combinations on Wednesday night in the Nets' first preseason game.
"I think we'll be able to play big, powerful," Atkins told the media via Nets Daily. "You could play Ed (Daivs) and Jarrett (Allen) together. You could go small with DeMarre (Carroll) at the 4 and I think (Rodions) Kurucs at the 5 today.
"And you watch in the games, the exhibition games right now. You just see a lot of guards out there. That was part of the thinking of tweaking the offence a little bit where it fits a four-guard system. I still like having that big guy out there, that one, Jarrett or Ed, just for rebounding and that rim-roller. But I definitely think we could see some more four-guard lineups."
For the Knicks, rookie Kevin Knox will head back on the court after putting up 13 points, 10 rebounds in his preseason debut against the Wizards. With no concrete starting lineup for the Knicks heading into the season, his minutes will be valuable for Knox to stake claim to a starting spot.
(Chicago Bulls @ Milwaukee Bucks - 8:00 p.m., NBATV Canada)
What to watch: Coach Budenholzer's offence
The Milwaukee Bucks might finally be able to play freely under Mike Budenholzer and the new offence. Giannis Anteketoumpo more specifically might be able to play freely under coach Bud.
The Bucks finished in the bottom five of the league last season in three-point attempts at 24.7.
Gone are the days of being encouraged to turn down three and welcome in a system that might open up driving lanes for Giannis and Eric Bledsoe. It might take a while, but you have to start somewhere and Wednesday night is the night.
(Detroit Pistons @ Oklahoma City Thunder - 8:00 p.m.)
What to watch: Andre Drummond's three-point shooting
Pistons' head coach Dwane Casey once gave Jonas Valanciunas the green light to hoist up triples, so Andre Drummond will certainly have his fair share of opportunity from deep.
Drummond has said he's worked on his three-point game and now we'll get to see him use his new tools in preseason at least.
Drummond and Blake Griffin launching threes this season for the Pistons could make for some interesting nights on the ole League Pass.
(New Zealand SKYCITY Breakers (NBL Australia) @ Phoenix Suns - 10:00 p.m.)
What to watch: DeAndre Ayton
With Devin Booker out with an injury, the number one overall pick DeAndre Ayton was able to feast in his debut against the Sacramento Kings finishing with 24 points, nine rebounds and three blocks.
His offensive production will eventually come to be expected, being the number one overall pick, but his true value might be defensively for the Suns. Joel Embiid has already famously called out Ayton's defence, Suns' fans are hoping he uses it as motivation.
(Minnesota Timberwolves @ Los Angeles Clippers - 10:30 p.m. NBATV Canada)
Watch to watch: Jimmy Butler
Let's face it it's preseason, this game really doesn't matter in the grand scheme of things, but anyone who's paying attention to the league knows that Jimmy Butler wants out of Minnesota.
Where Jimmy goes is the league's biggest story, and everyone has their favourite newsbreaker's tweet notification on waiting for it to happen.
If you do end up watching this game however maybe the Clippers' broadcast with air another episode of "Bobi and Tobi" to distract you for a couple minutes on the true story of this game - when will Jimmy get traded?!